Genetic and epigenetic contributors to FSHD
نویسندگان
چکیده
منابع مشابه
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متن کاملCommon epigenetic changes of D4Z4 in contraction-dependent and contraction-independent FSHD.
Facioscapulohumeral muscular dystrophy (FSHD), caused by partial deletion of the D4Z4 macrosatellite repeat on chromosome 4q, has a complex genetic and epigenetic etiology. To develop FSHD, D4Z4 contraction needs to occur on a specific genetic background. Only contractions associated with the 4qA161 haplotype cause FSHD. In addition, contraction of the D4Z4 repeat in FSHD patients is associated...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2015
ISSN: 0959-437X
DOI: 10.1016/j.gde.2015.08.007